Not sure if this has been posted but this
article details a "too soon" attempt at human genetic editing.
With implanted the embryos.
With potential germ line effects at that.
Summary: Chinese unethical scientist modifies two twins in an attempt to make them immune to HIV by a precise deletion in the CCR5 protein. Will the deletion even work to make them immune? Who knows?
The technique is too early and immature to properly perform that deletion. Off target effects are expected, one twin had 15 bases deleted, the other had 4 (!!) deleted and in some cells 1 added.
This is important because DNA bases -> protein translation happens in groups of 3, if you delete or add a number not divisible by 3, you screw up the rest of the protein.
Some of the cells did not have *both* copies edited, meaning those cells have gene editing side effects without the immunity at all.
Given that not every cell was edited at the same time, means that the twins contain an unknown amount of mosaicism. They may or may not pass it on to their children if they have any...
The worst part of course is that this sort of mass editing program could have be done on bone marrow cells in order to make a transplanted immune system immune to HIV. It would have been much easier to do, much more controllable and if failed, the transplant could have just been junked instead.
The sad part about this whole issue is that this scientist has done more to damage the cause of pro-gene editing stances (which I subscribe to). By doing this too early, without practicing on non-implanted eggs first to fix the problems listed above, he risks causing a backlash against the whole genetic editing research field.