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by qetzal
Sun Feb 25, 2018 5:14 pm UTC
Forum: Serious Business
Topic: Are patents/IP good for innovation?
Replies: 67
Views: 12218

Re: Are patents/IP good for innovation?

Modifying IP patents to automatically give the creator automatic massive revenue while removing their ability to excessively price gouge the US is not nearly so huge a overhaul. Mybe so, but it’s far from obvious to me how you could do that successfully. I think it would be easier to work on allowi...
by qetzal
Sun Feb 25, 2018 4:04 am UTC
Forum: Serious Business
Topic: Are patents/IP good for innovation?
Replies: 67
Views: 12218

Re: Are patents/IP good for innovation?

I get that. When it comes to costs, the US healthcare system is ridiculous. But I don’t see how that’s related to patents. Especially since every other developed nation (including Switzerland) has a virtually identical patent system as the US. Unless the inventors of Sovaldi chose not to pursue a pa...
by qetzal
Sun Feb 25, 2018 12:15 am UTC
Forum: Serious Business
Topic: Are patents/IP good for innovation?
Replies: 67
Views: 12218

Re: Are patents/IP good for innovation?

Sovaldi is unusual because for most, it’s a cure for a disease that has a high mortality rate. So it’s at least arguably worth the high price. After all, isn’t an extra 10 or 20 years of life worth $150K? Humira is a much better example, because as you say, it’s not a curr, just a treatment, yet sti...
by qetzal
Sat Feb 24, 2018 9:27 pm UTC
Forum: Serious Business
Topic: Are patents/IP good for innovation?
Replies: 67
Views: 12218

Re: Are patents/IP good for innovation?

Sovaldi is a pretty unusual case, in both good and bad ways. Probably not appropriate to revise an entire system based on real or perceived injustices in edge cases. FWIW, however, the reason it’s so much cheaper in India is because they apparently couldn’t get it patented there. Some may consider t...
by qetzal
Sat Feb 24, 2018 2:22 pm UTC
Forum: Serious Business
Topic: Are patents/IP good for innovation?
Replies: 67
Views: 12218

Re: Are patents/IP good for innovation?

Take away the patents, and they would still seek to fund new drugs. Do you really think people will come together and pool their resources to the tune of several hundred million dollars over a 10 year period, to get a single drug approved, knowing that IF they’re successful, someone else can sell t...
by qetzal
Sat Feb 24, 2018 4:59 am UTC
Forum: Serious Business
Topic: Are patents/IP good for innovation?
Replies: 67
Views: 12218

Re: Are patents/IP good for innovation?

I don’t buy that. Nothing stops a crowdsourced group from discovering and patenting their own drugs. And if they did so, the patent would give them legal protection against any unscrupulous pharmas that might try to steal their invention. Plus, if it was as straightforward as you suggest, they’d als...
by qetzal
Sat Feb 24, 2018 4:23 am UTC
Forum: Serious Business
Topic: Are patents/IP good for innovation?
Replies: 67
Views: 12218

Re: Are patents/IP good for innovation?

The people who are going to be selling a potential new drug already fund its development. That’s just pharma. I admit I’m not aware of many/any cases where potential users have funded drug development. At least, not sufficiently to get a drug approved and marketed. But I think that’s pretty unsurpri...
by qetzal
Sat Feb 24, 2018 3:54 am UTC
Forum: Serious Business
Topic: Are patents/IP good for innovation?
Replies: 67
Views: 12218

Re: Are patents/IP good for innovation?

Yeah, that’s a possible option I suppose. Of course, that could happen right now, without changing the patent system at all. But in fact, academics virtually never take new drug discoveries through to approval and commercialization. I suspect there are lessons to be learned from that observation, bu...
by qetzal
Sat Feb 24, 2018 3:37 am UTC
Forum: Serious Business
Topic: Are patents/IP good for innovation?
Replies: 67
Views: 12218

Re: Are patents/IP good for innovation?

Inventions are free could work fine in some fields. Especially where the inventor can commercialize the invention rapidly and benefit for a period of time just based on his head start over orhers. But what do you think it would do in fields where there’s a huge lag between invention and commercializ...
by qetzal
Fri Feb 23, 2018 5:09 pm UTC
Forum: Serious Business
Topic: Are patents/IP good for innovation?
Replies: 67
Views: 12218

Re: Are patents/IP good for innovation?

Are you suggesting this scheme specifically as a way to deal with patent trolls? If so, I don't understand why this is a good solution. Patent trolling i about trying to force people to license patents that don't really need, or that should never have even been granted. The better solution to that, ...
by qetzal
Fri Feb 16, 2018 4:10 am UTC
Forum: Science
Topic: Hardy-Weinberg Equilibrium Help
Replies: 10
Views: 3481

Re: Hardy-Weinberg Equilibrium Help

Just imagine a situation where AB heterozygotes are lethal.
by qetzal
Sat Jan 13, 2018 3:46 am UTC
Forum: Science
Topic: Sugar and Vitamin/Mineral Absorption
Replies: 8
Views: 2806

Re: Sugar and Vitamin/Mineral Absorption

The reason this is wrong is that Mg and Ca don’t get “used up” during these reactions. They are co-factors for a variety of enzymes, and like the enzymes, they only help catalyze the reactions. They get used for that over and over. Plus, they are already in every cell of your body. They don’t have t...
by qetzal
Sat Mar 04, 2017 11:42 pm UTC
Forum: Serious Business
Topic: An essay against competition
Replies: 50
Views: 19275

Re: An essay against competition

qetzal: But that is exactly where we disagree. A computational process is a model that includes a computer plus information (both of them concrete material things). The model fits all three of your examples, although you have left out some of the components. The thought process uses information in ...
by qetzal
Tue Feb 21, 2017 10:51 pm UTC
Forum: Serious Business
Topic: An essay against competition
Replies: 50
Views: 19275

Re: An essay against competition

A human is not a thought process, any more than a computer is Microsoft Excel, or than a species' genome is evolution.
by qetzal
Sun Jan 29, 2017 8:35 pm UTC
Forum: Serious Business
Topic: An essay against competition
Replies: 50
Views: 19275

Re: An essay against competition

It's not that the explanations in your essay are too long. It's that they're not logical or persuasive. Regarding thought vs. evolution, you really only have a single paragraph (at the end of Chapter 10): The human thought process is more efficient than evolution. The difference in efficiency is the...
by qetzal
Sat Jan 28, 2017 6:12 pm UTC
Forum: Serious Business
Topic: An essay against competition
Replies: 50
Views: 19275

Re: An essay against competition

reval, A key difficulty, at least for me, is that you make many claims and assertions that are unsupported and not self-evident (if not simply wrong). Take this paragraph: "When I am advancing my genetic information, my motive is competitive. Always more are born than can live. When I am advanc...
by qetzal
Sat Jan 28, 2017 5:55 am UTC
Forum: Serious Business
Topic: An essay against competition
Replies: 50
Views: 19275

Re: An essay against competition

As noted previously, competition and cognition are not opposites and they're not mutually exclusive. Cognition is also not an alternative to evolution. Claiming that the thought process is "more efficient and powerful" than evolution is quit frankly nonsensical. It's a bit like claiming th...
by qetzal
Thu Apr 28, 2016 11:17 pm UTC
Forum: News & Articles
Topic: Supermyths: Myths About Debunking Myths
Replies: 30
Views: 7475

Re: Supermyths: Myths About Debunking Myths

Actually, I don't think you can blame the debunkers here at all. Consider that first, there was the myth that spinach has a lot of iron. Then, that myth was debunked, but it must have been debunked for good reasons. It couldn't have been debunked based on the misplaced decimal story, because that (a...
by qetzal
Thu Mar 03, 2016 10:07 pm UTC
Forum: Science
Topic: Problems in medical research:Tracking outcome switching
Replies: 90
Views: 10797

Re: Problems in medical research:Tracking outcome switching

To be blunt, what you're saying is wrong. ObvioUsly I'm explaining poorly, so please do some reading on your own. It's not easy to grasp, and I freely admit it took me quite a while to understand, but it's woth the effort.
by qetzal
Thu Mar 03, 2016 8:27 pm UTC
Forum: Science
Topic: Problems in medical research:Tracking outcome switching
Replies: 90
Views: 10797

Re: Problems in medical research:Tracking outcome switching

If we get p < 0.01 that means our difference highly likely (with 99.00 percent certainty) did not happen due to chance or random factors such as sampling error, but due to existing difference between population groups. This is wrong. As a starting point, try the Wikipedia article on p-value, which ...
by qetzal
Thu Mar 03, 2016 2:15 pm UTC
Forum: Science
Topic: Problems in medical research:Tracking outcome switching
Replies: 90
Views: 10797

Re: Problems in medical research:Tracking outcome switching

It sounds like you're conflating two distinct issues here. Publication bias, where negative results don't get published, can make us think an effect is real even when it's not. That's because we might only see the results of the few studies that randomly produce a false positive result, but we don'...
by qetzal
Wed Mar 02, 2016 4:31 am UTC
Forum: Science
Topic: Problems in medical research:Tracking outcome switching
Replies: 90
Views: 10797

Re: Problems in medical research:Tracking outcome switching

Your statement was "Reporting all studies is the only way we can judge whether the apparent statistical significance of one study is actually significant." My mistake as well, I used the term 'apparent statistical significance' - there is no apparent statistical significance - the differe...
by qetzal
Sun Feb 21, 2016 4:11 am UTC
Forum: Science
Topic: Problems in medical research:Tracking outcome switching
Replies: 90
Views: 10797

Re: Problems in medical research:Tracking outcome switching

Well first of all, hiding negative date is not the same as hiring corrupt or incompetent researchers to generate fraudulent data, which was HungryHobo's claim. Second, drug developers can and do manipulate which data they publish, but it's much harder for them to conceal negative data from the regul...
by qetzal
Sun Feb 21, 2016 1:16 am UTC
Forum: Science
Topic: Problems in medical research:Tracking outcome switching
Replies: 90
Views: 10797

Re: Problems in medical research:Tracking outcome switching

Yes, crap drugs to get through. I don't dispute that. I dispute that crap drugs frequently get through because drug companies can just hire a few corrupt, naïve, or incompetent researchers.
by qetzal
Sun Feb 21, 2016 12:01 am UTC
Forum: Science
Topic: Problems in medical research:Tracking outcome switching
Replies: 90
Views: 10797

Re: Problems in medical research:Tracking outcome switching

Once you've spent hundreds of millions getting to stage 3 trials there's a strong incentive to corrupt a few naive researchers and skew a few results if it means making back the cost's to that point. The marketing goons don't give a flying fuck if the drug works or not, all they care about is wheth...
by qetzal
Thu Dec 31, 2015 8:03 pm UTC
Forum: News & Articles
Topic: Creationists twist themselves into a knot
Replies: 11
Views: 5021

Re: Creationists twist themselves into a knot

I'm still trying to figure out who has made the argument that a cat can give birth to a chicken. I don't know about cats giving birth to chicken, but Utah State Sen. Chris Buttars thought he could refute evolution by saying, "We get different types of dogs and different types of cats, but you ...
by qetzal
Mon Dec 28, 2015 4:56 am UTC
Forum: Science
Topic: Data presentation (Graphical design guru needed!)
Replies: 8
Views: 3966

Re: Data presentation (Graphical design guru needed!)

Your X axis seems very problematic to me. The first interval spans 10k, the next 15, then 25, then 50, then 150, and then everything larger. Is there any justification for that? Seems to me your apparent increase in B and C may disappear if you used equivalent sized bins.
by qetzal
Fri Dec 25, 2015 4:30 am UTC
Forum: News & Articles
Topic: The profit ethic at work!
Replies: 55
Views: 11531

Re: The profit ethic at work!

That would be great if that holds up. From the little I've read though, it seems to still be in dispute. E.g. See https://www.bakerlaw.com/files/uploads/ ... elgene.pdf.

But IANAL.
by qetzal
Thu Dec 24, 2015 3:27 pm UTC
Forum: News & Articles
Topic: The profit ethic at work!
Replies: 55
Views: 11531

Re: The profit ethic at work!

There are a few different issues at play here. In the case of Daraprim & Turing, that's a drug that's off-patent. Ordinarily, a generics drug manufacturer would have been able to get their own version of the same drug approved by FDA. Since the original version is (presumably) already proven to ...
by qetzal
Sun Dec 06, 2015 2:51 am UTC
Forum: News & Articles
Topic: The profit ethic at work!
Replies: 55
Views: 11531

Re: The profit ethic at work!

@sardia I don't see where your link says drug companies lobbied in favor of FDA's restricted distribution rules. And in any case, this link http://healthaffairs.org/blog/2015/10/21/the-daraprim-price-hike-and-a-role-for-antitrust/ sats Daraprim isn't covered by such FDA restrictions anyway. Skreli's...
by qetzal
Tue Nov 24, 2015 3:44 am UTC
Forum: Logic Puzzles
Topic: Escape the Frictionless Circle
Replies: 156
Views: 52352

Re: Escape the Frictionless Circle

Or, what if you rub one side of the gold block, making that side get warmer. Could that do anything? Maybe the higher temp of that side would slightly increase the (infinitesimal) evaporation rate of gold atoms, creating a *tiny* net force on that side? 😀 Edit: More seriously, would the following wo...
by qetzal
Mon Nov 23, 2015 11:00 pm UTC
Forum: News & Articles
Topic: My Friend was Killed in a Terrorist Attack
Replies: 9
Views: 4862

Re: My Friend was Killed in a Terrorist Attack

Yes, if you want people to sign this, the least you should do is back up the factual claims in the petition.
by qetzal
Mon Aug 24, 2015 2:11 am UTC
Forum: Logic Puzzles
Topic: Three Cards Trick
Replies: 15
Views: 2811

Re: Three Cards Trick

i think kamenf gave the clue above. Besides the order of the cards on the table, there's also the order that the Assistant names them. That allows 36 different combos. And that should be plenty because there are really only 17 permutations needed: 13 for the rank (2-A) and 4 for the suit.
by qetzal
Sun Aug 23, 2015 1:00 pm UTC
Forum: Science
Topic: Doctor/Quack/Shill Vitamin D?
Replies: 14
Views: 3486

Re: Doctor/Quack/Shill Vitamin D?

If he's recommending chiropracty, I'd strongly consider finding a new doc. Conventional chiropracty is quackery. They believe that all illnesses are due to blockages of "innate intelligence" and that they can be cured by adjusting your spine to unblock the flow. Which is baloney. Now, the...
by qetzal
Sat Aug 22, 2015 9:24 pm UTC
Forum: Science
Topic: Doctor/Quack/Shill Vitamin D?
Replies: 14
Views: 3486

Re: Doctor/Quack/Shill Vitamin D?

If he's recommending chiropracty, I'd strongly consider finding a new doc. Conventional chiropracty is quackery. They believe that all illnesses are due to blockages of "innate intelligence" and that they can be cured by adjusting your spine to unblock the flow. Which is baloney. Now, ther...
by qetzal
Sun Aug 09, 2015 11:32 pm UTC
Forum: Serious Business
Topic: The Ethics of Genetic Engineering
Replies: 215
Views: 42206

Re: The Ethics of Genetic Engineering

If your point is that directors won't spend money to ID genetic causes of diseases, for fear that will lead to people demanding genetic fixes for those diseases, I think you're wrong. There may be someone somewhere who's taken that position, but I don't believe it's a real issue. As for screening, I...
by qetzal
Mon Aug 03, 2015 2:18 pm UTC
Forum: Serious Business
Topic: The Ethics of Genetic Engineering
Replies: 215
Views: 42206

Re: The Ethics of Genetic Engineering

Spleen, Actually, I am in the US. And, having worked for roughly a decade in human gene therapy and closely related fields, I like to think I have some insight here as well. :) I completely agree that US & EU research organizations don't want to get involved in embryonic or germ-line genetic mod...
by qetzal
Sun Aug 02, 2015 1:23 pm UTC
Forum: Serious Business
Topic: The Ethics of Genetic Engineering
Replies: 215
Views: 42206

Re: The Ethics of Genetic Engineering

The only thing that would be considered shocking is that some boards of directors etc, do not even allow research in the genetic cause of a number of illnesses because there then would be a potential risk we might make a study coming up with a GM cure later on. Which in turn would make it possible ...
by qetzal
Sun Aug 02, 2015 1:11 pm UTC
Forum: Serious Business
Topic: Dairy or dairy-free alternative?
Replies: 37
Views: 11508

Re: Dairy or dairy-free alternative?

Sableagle wrote:Producing milk's incredibly inefficient in terms of water and land use...


Seems like the obvious choice is water.
by qetzal
Wed Jun 24, 2015 1:49 pm UTC
Forum: Science
Topic: Noise Muffling: Locked vs Unlocked Window
Replies: 13
Views: 2295

Re: Noise Muffling: Locked vs Unlocked Window

If your window is like some of mine, latching may also close it tighter, eliminating some gaps where the sound was coming through.

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